Arsenic and Old Lace is a play by American playwright Joseph Kesselring, written in 1939. It has become best known through the 1944 film adaptation starring Cary Grant and directed by Frank Capra.

Arsenic and Old Lace is a 1944 American screwball mystery black comedy film directed by Frank Capra and starring Cary Grant. The screenplay by Julius J. Epstein and Philip G. Epstein is based on Joseph Kesselring's 1941 play of the same name. The contract with the play's producers stipulated that the film would not be released until the Broadway run ended. The original planned release date was September 30, 1942. The play was hugely successful, running for three and a half years, so the film was not released until 1944.