Central is the largest of Botswana's districts in terms of area and population. It encompasses the traditional homeland of the Bamangwato people. Some of the most politically connected Batswana have come from the Central District, including former President Sir Seretse Khama, former President Festus Mogae, and former President Lt. General Seretse Ian Khama. The district borders the Botswanan districts of Chobe in the north, North-West in the northwest, Ghanzi in the west, Kweneng in southwest, Kgatleng in the south and North-East in the northeast, as well as Zimbabwe also in the northeast and South Africa in the southeast.

Sir Seretse Goitsebeng Maphiri Khama, GCB, KBE was a Botswana politician who served as the first President of Botswana, a post he held from 1966 to his death in 1980.