Cholula was an important city of pre-Columbian Mesoamerica, dating back to at least the 2nd century BCE, with settlement as a village going back at least some thousand years earlier. The site of Cholula is just west of the modern city of Puebla and served as a trading outpost. Its immense pyramid is the largest such structure in the Americas, and the largest pyramid structure by volume in the world, measuring 4.45 million cubic meters.

In the history of the Americas, the pre-Columbian era, also known as the pre-contact era, spans from the original peopling of the Americas in the Upper Paleolithic to European colonization, which began with Christopher Columbus's voyage of 1492. Usually, the era covers the history of Indigenous cultures until significant influence by Europeans. This may have occurred decades or even centuries after Columbus for certain cultures.