Columbus is a city in and the county seat of Lowndes County, on the eastern border of Mississippi, United States, located primarily east, but also north and northeast of the Tombigbee River, which is also part of the Tennessee-Tombigbee Waterway. It is approximately 146 miles (235 km) northeast of Jackson, 92 miles (148 km) north of Meridian, 63 miles (101 km) south of Tupelo, 60 miles (97 km) northwest of Tuscaloosa, Alabama, and 120 miles (193 km) west of Birmingham, Alabama.

Lowndes County is a county on the eastern border of the U.S. state of Mississippi. As of the 2020 United States Census, the population was 58,879. Its county seat is Columbus. The county is named for U.S. Congressman William Jones Lowndes.