Comanche County is a county located in the U.S. state of Oklahoma. As of the 2020 census, the population was 121,125, making it the fifth-most populous county in Oklahoma. Its county seat is Lawton. The county was created in 1901 as part of Oklahoma Territory. It was named for the Comanche tribal nation.

Lawton is a city in and the county seat of Comanche County, in the U.S. state of Oklahoma. Located in southwestern Oklahoma, approximately 87 mi (140 km) southwest of Oklahoma City, it is the principal city of the Lawton, Oklahoma, metropolitan statistical area. According to the 2020 census, Lawton's population was 90,381, making it the sixth-largest city in the state, and the largest in Western Oklahoma.