County Route 533 is a county highway in the U.S. state of New Jersey. The highway extends 32.78 miles (52.75 km) from the White Horse Circle, in Hamilton Township to Middlesex CR 607 on the border of Bound Brook and Middlesex Borough. CR 533 shares a long concurrency with U.S. Route 206 through Princeton and Montgomery Township, while portions of the roadway in Somerset County are part of the Millstone River Valley Scenic Byway.

Hamilton Township is a township and the most populous municipality in Mercer County, in the U.S. state of New Jersey. It is the largest suburb of Trenton, the state's capital, which is located to the township's west. The township is situated within the New York metropolitan area as defined by the United States Census Bureau but directly borders the Philadelphia metropolitan area and is part of the Federal Communications Commission's Philadelphia Designated Market Area. As of the 2020 United States census, the township's population was 92,297, its highest decennial count ever and an increase of 3,833 (+4.3%) from the 2010 census count of 88,464, which in turn reflected an increase of 1,355 (+1.6%) from the 2000 census count of 87,109. The township was the state's ninth-largest municipality in 2010 and 2020, after having been ranked 10th in 2000.