"Ends of the Earth" is a comic book storyline in The Amazing Spider-Man published by Marvel Comics in 2012. The villains of the story are the Sinister Six, who are led by Spider-Man's arch-enemy Doctor Octopus. Unlike the prior event story "Spider-Island" there is only one tie-in issue instead of the multitude of tie-in issues involved with that story; the story is completely contained within issues #682-687 of The Amazing Spider-Man. The storyline received positive reviews, with critics praising the action, the plot, and the art style.

The Amazing Spider-Man is an ongoing American superhero comic book series featuring the Marvel Comics superhero Spider-Man as its title character and main protagonist. Being in the mainstream continuity of the franchise, it was the character's first title, launching seven months after his introduction in the final issue of Amazing Fantasy. The series began publication with a March 1963 cover date and has been published nearly continuously to date over six volumes with only one significant interruption. Issues of the title currently feature an issue number within its sixth volume, as well as a "legacy" number reflecting the issue's overall number across all Amazing Spider-Man volumes. The title reached 900 issues in 2022.