Francis I of Lorraine, 2nd Duke of Guise, 1st Prince of Joinville, and 1st Duke of Aumale, was a French general and statesman. A prominent leader during the Italian War of 1551–1559 and French Wars of Religion, he was assassinated during the siege of Orleans in 1563.

The Italian War of 1551–1559 began when Henry II of France declared war against Holy Roman Emperor Charles V with the intent of recapturing parts of Italy and ensuring French, rather than Habsburg, domination of European affairs. The war ended following the signing of the Treaty of Cateau-Cambrésis between the monarchs of Spain, England and France in 1559. Historians have emphasized the importance of gunpowder technology, new styles of fortification to resist cannon fire, and the increased professionalization of the soldiers.