Fulton County is a county in the U.S. state of New York. It forms part of the state's Mohawk Valley region. Its county seat is Johnstown. At the 2020 U.S. census, the county had a population of 53,324. The county is named in honor of Robert Fulton, who is widely credited with developing the first commercially successful steamboat. The county is part of the Mohawk Valley region of the state.

The Mohawk Valley region of the U.S. state of New York is the area surrounding the Mohawk River, sandwiched between the Adirondack Mountains and Catskill Mountains, northwest of the Capital District. As of the 2010 United States Census, the region's counties have a combined population of 622,133 people. In addition to the Mohawk River valley, the region contains portions of other major watersheds such as the Susquehanna River.