Grafton is a city in and the county seat of Taylor County, West Virginia, United States, along the Tygart Valley River. The population was 4,729 at the 2020 census. It originally developed as a junction point for the Baltimore and Ohio Railroad, serving numerous branches of a network that was vital to the regional coal industry.

Taylor County is a county in the U.S. state of West Virginia. As of the 2020 census, the population was 16,705. Its county seat is Grafton. The county was formed in 1844 and named for Senator John Taylor of Caroline.