The city of Harrison is the county seat of Boone County, Arkansas, United States. It is named after Marcus LaRue Harrison, a surveyor who laid out the city along Crooked Creek at Stifler Springs. According to 2019 Census Bureau estimates, the population of the city was 13,069, up from 12,943 at the 2010 census and it is the 30th largest city in Arkansas based on official 2019 estimates from the U.S. Census Bureau. Harrison is the principal city of the Harrison Micropolitan Statistical Area, which includes all of Boone and Newton counties.

Boone County is located in the U.S. state of Arkansas, along the Missouri border. As of the 2020 census, the population was 37,373. The county seat is Harrison. It is Arkansas's 62nd county, formed on April 9, 1869.