Independence County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 37,938. The county seat is Batesville. Independence County is Arkansas's ninth county, formed on October 20, 1820, from a portion of Lawrence County and named in commemoration of the Declaration of Independence. It is an alcohol prohibition or dry county.

Batesville is the county seat and largest city of Independence County, Arkansas, United States, 80 miles (183 km) northeast of Little Rock, the state capital. According to the 2010 Census, the population of the city was 10,268. The city serves as a regional manufacturing and distribution hub for the Ozark Mountain region and Northeast Arkansas.