Itta Bena is a city in Leflore County, Mississippi, United States. The population was 2,049 at the 2010 census. The town's name is derived from the Choctaw phrase iti bina, meaning "forest camp". Itta Bena is part of the Greenwood, Mississippi micropolitan area. It developed as a trading center of an area of cotton plantations.

Leflore County is a county located in the U.S. state of Mississippi. As of the 2020 census, the population was 28,339. The county seat is Greenwood. The county is named for Choctaw leader Greenwood LeFlore, who signed a treaty to cede his people's land to the United States in exchange for land in Indian Territory. LeFlore stayed in Mississippi, settling on land reserved for him in Tallahatchie County.