Jacksonville is a city in Calhoun County, Alabama, United States. As of the 2020 census the population was 14,385, which is a 14.6% increase since 2010 and a 71.2% increase since 2000. It is included in the Anniston-Oxford Metropolitan Statistical Area. The city is home to Jacksonville State University, which is a center of commerce and one of the largest employers in the area.

Calhoun County is a county in the east central part of the U.S. state of Alabama. As of the 2020 census, the population was 116,441. Its county seat is Anniston. It is named in honor of John C. Calhoun, a US Senator from South Carolina.