Kenedy County is a county located in the U.S. state of Texas. As of the 2020 census, its population was 350. It is the third-least populous county in Texas and fourth-least populous in the United States. Its county seat is Sarita. The county was created in 1921 from parts of Hidalgo and Willacy counties and is named for Mifflin Kenedy, an early area rancher and steamboat operator.

In 45 of the 50 states of the United States, the county is used for the level of local government immediately below the state itself. Louisiana uses parishes, and Alaska uses boroughs. In Connecticut, Massachusetts, and Rhode Island, some or all counties within states have no governments of their own; the counties continue to exist as legal entities, however, and are used by states for some administrative functions and by the United States Census bureau for statistical analysis. There are 3,242 counties and county equivalent administrative units in total, including the District of Columbia and 100 county-equivalents in the U.S. territories.