The Klamath Mountains ecoregion of Oregon and California lies inland and north of the Coast Range ecoregion, extending from the Umpqua River in the north to the Sacramento Valley in the south. It encompasses the highly dissected ridges, foothills, and valleys of the Klamath and Siskiyou Mountains. It corresponds to the Level III ecoregion designated by the Environmental Protection Agency and to the Klamath-Siskiyou forests ecoregion designated by the World Wide Fund for Nature.

The Klamath Mountains are a rugged and lightly-populated mountain range in northwestern California and southwestern Oregon in the western United States. As a mountain system within both the greater Pacific Coast Ranges and the California Coast Ranges, the Klamath Mountains have a varied geology, with substantial areas of serpentinite and marble, and a climate characterized by moderately cold winters with very heavy snowfall and warm, very dry summers with limited rainfall, especially in the south. As a consequence of the geology and soil types, the mountains harbor several endemic or near-endemic trees, forming one of the largest collections of conifers in the world. The mountains are also home to a diverse array of fish and animal species, including black bears, large cats, owls, eagles, and several species of Pacific salmon. Millions of acres in the mountains are managed by the United States Forest Service. The northernmost and largest sub-range of the Klamath Mountains are the Siskiyou Mountains.