Lamesa is a city in and the county seat of Dawson County, Texas, United States. The population was 8,674 at the 2020 census, down from 9,952 at the 2000 census. Located south of Lubbock on the Llano Estacado, Lamesa was founded in 1903. Most of its economy is based on cotton farming. The Preston E. Smith prison unit, named for the former governor of Texas, is located just outside Lamesa.

Dawson County is a county in the U.S. state of Texas. As of the 2020 census, its population was 12,456. The county seat is Lamesa. The county was created in 1876 and later organized in 1905. It is named for Nicholas Mosby Dawson, a soldier of the Texas Revolution. Dawson County comprises the Lamesa, TX Micropolitan Statistical Area (μSA), and it is, by population, the smallest Micropolitan Statistical Area in the United States.