Lyme is a town in New London County, Connecticut, United States, situated on the eastern side of the Connecticut River. The town is part of the Lower Connecticut River Valley Planning Region. The population was 2,352 at the 2020 census. Lyme is the eponym of Lyme disease.

New London County is in the southeastern corner of Connecticut and comprises the Norwich-New London, Connecticut Metropolitan Statistical Area, which is also included in the Hartford-East Hartford, Connecticut Combined Statistical Area. There is no county government and no county seat, as is the case with all eight of Connecticut's counties; towns are responsible for all local government activities, including fire and rescue, snow removal, and schools.