The Mercedes-Benz W220 was a range of flagship sedans which, as the fourth generation Mercedes-Benz S-Class, replaced the W140 S-Class after model year 1998 — with long and short wheelbase versions, performance and luxury options; available four-wheel drive; and a range of diesel as well as gas/petrol V6, V8, and V12 engines. Compared to its predecessor, the W220 had somewhat smaller exterior dimensions but offered greater interior volume, particularly in the long-wheelbase versions, and slightly less cargo volume.

The Mercedes-Benz S-Class, formerly known as Sonderklasse, is a series of full-sized luxury sedans, limousines and armored sedans produced by the German automaker Mercedes-Benz. The S-Class is the designation for top-of-the-line Mercedes-Benz models and was officially introduced in 1972 with the W116, and has remained in use ever since. The S-Class is the flagship vehicle for Mercedes-Benz and is positioned above the other models.