The Methodist Episcopal Church, South was the American Methodist denomination resulting from the 19th-century split over the issue of slavery in the Methodist Episcopal Church (MEC). Disagreement on this issue had been increasing in strength for decades between churches of the Northern and Southern United States; in 1845 it resulted in a schism at the General Conference of the MEC held in Louisville, Kentucky.

The Methodist Episcopal Church (MEC) was the oldest and largest Methodist denomination in the United States from its founding in 1784 until 1939. It was also the first religious denomination in the US to organize itself nationally. In 1939, the MEC reunited with two breakaway Methodist denominations to form the Methodist Church. In 1968, the Methodist Church merged with the Evangelical United Brethren Church to form the United Methodist Church.