The Mitchell River is a river in Far North Queensland, Australia. The river rises on the Atherton Tableland about 50 kilometres (31 mi) northwest of Cairns and flows about 750 kilometres (470 mi) northwest across Cape York Peninsula from Mareeba to the Gulf of Carpentaria.

Far North Queensland (FNQ) is the northernmost part of the Australian state of Queensland. Its largest city is Cairns and it is dominated geographically by Cape York Peninsula, which stretches north to the Torres Strait, and west to the Gulf Country. The waters of Torres Strait include the only international border in the area contiguous with the Australian mainland, between Australia and Papua New Guinea.