My Sister Eileen is an American situation comedy broadcast during the 1960–1961 television season. It depicts the lives of two sisters, one a writer and the other an actress, who move to New York City to further their careers.

My Sister Eileen is a series of autobiographical short stories by Ruth McKenney, originally published in The New Yorker, which eventually inspired many other works: her 1938 book My Sister Eileen, a play, a musical, a radio play, two motion pictures, and a CBS television series in the 1960–1961 season.