Nelsonville is a city in northwestern Athens County, Ohio, United States, located about 60 miles (97 km) southeast of Columbus. The population was 5,373 at the 2020 census. It is home to Hocking College as well as Rocky Brands. Nelsonville is surrounded by Ohio's only national forest, the Wayne National Forest.

Athens County is a county in southeastern Ohio. As of the 2020 census, the population was 62,431. Its county seat and largest city is Athens. The county was formed in 1805 from Washington County. Because Ohio's first state university, Ohio University, was established here in 1804, the town and the county are named for the ancient center of learning, Athens, Greece.