North Avenue is a major east–west street in Chicago, Illinois, and its western suburbs. Starting at St. Charles's eastern border with West Chicago, its name changes from Main Street to North Avenue, just east of the Kane/DuPage county line. From there, it travels straight east, carrying Illinois Route 64 until LaSalle Drive in Chicago. Illinois Route 64 then continues north onto LaSalle Drive for a very short distance until ending at U.S. Route 41, while North Avenue continues east for less than one-half mile, changing its name to North Boulevard at Clark Street, and then continuing until its termination in a cul-de-sac at 200 East, just west of Lake Shore Drive. From Illinois Route 43 to its east end, North Avenue is within the city limits of Chicago.

Illinois Route 64 is an east–west state highway in Northern Illinois. Its western terminus is at the Iowa state line, connecting with U.S. Route 52 (US 52) and Iowa Highway 64 via the Dale Gardner Veterans Memorial Bridge at the Mississippi River west of Savanna. IL 64 then travels east through Mount Carroll, Lanark, Mount Morris, Oregon, Sycamore, Lily Lake, Saint Charles and the western suburbs of Chicago before terminating at U.S. Route 41 on the city's north side. IL 64 is 138.61 miles (223.07 km) long.