Ohio County is a county located in the Northern Panhandle of the U.S. state of West Virginia. As of the 2020 census, the population was 42,425. Its county seat is Wheeling. The county was formed in 1776 from the District of West Augusta, Virginia. It was named for the Ohio River, which forms its western boundary with the state of Ohio. West Liberty was designated as the county seat in 1777, serving to 1797.

Wheeling is a city in the U.S. state of West Virginia. Located almost entirely in Ohio County, of which it is the county seat, it lies along the Ohio River in the foothills of the Appalachian Mountains and also contains a tiny portion extending into Marshall County. Wheeling is located about 60 miles (96 km) west of Pittsburgh and is the principal city of the Wheeling metropolitan area. As of the 2020 census, the city had a population of 27,062, and the metro area had a population of 139,513. It is the fifth most populous city in West Virginia, and the most populous in the state’s Northern Panhandle.