The 2012 Royal Rumble was the 25th annual Royal Rumble professional wrestling pay-per-view (PPV) event produced by WWE. It took place on January 29, 2012, at the Scottrade Center in St. Louis, Missouri. As has been customary since 1993, the Royal Rumble match winner received a world championship match at that year's WrestleMania. For the 2012 event, the winner received their choice to challenge for either the WWE Championship or World Heavyweight Championship at WrestleMania XXVIII. It was the first Royal Rumble held since the end of the first brand extension in August 2011.

The Enterprise Center is an 18,096-seat arena located in downtown St. Louis, Missouri, United States. Its primary tenant is the St. Louis Blues of the National Hockey League, but it is also used for other functions, such as NCAA basketball, NCAA hockey, concerts, professional wrestling and more. In a typical year, the facility hosts about 175 events. Industry trade publication Pollstar has previously ranked Enterprise Center among the top ten arenas worldwide in tickets sold to non-team events, but the facility has since fallen into the upper sixties, as of 2017.