San Isidro is a city in Greater Buenos Aires. It is located 27.9 km from the Autonomous City of Buenos Aires (CABA). It ranks as the province's most affluent neighborhood.

Greater Buenos Aires, also known as the Buenos Aires Metropolitan Area, refers to the urban agglomeration comprising the Autonomous City of Buenos Aires and the adjacent 24 partidos (districts) in the Province of Buenos Aires. Thus, it does not constitute a single administrative unit. The conurbation spreads south, west and north of Buenos Aires city. To the east, the River Plate serves as a natural boundary.