The Uprising in Serbia was initiated in July 1941 by the Communist Party of Yugoslavia against the German occupation forces and their Serbian quisling auxiliaries in the Territory of the Military Commander in Serbia. At first the Yugoslav Partisans mounted diversions and sabotage and attacked representatives of Milan Aćimović's quisling administration. In late August some Chetniks joined the uprising and liberated Loznica. The uprising soon reached mass proportions. Partisans and Chetniks captured towns that weak German garrisons had abandoned. The armed uprising soon engulfed great parts of the occupied territory. The largest liberated territory in occupied Europe was created by the Partisans in western Serbia, and was known as the Republic of Užice. Rebels shared power on the liberated territory; the center of the Partisan liberated territory was in Užice, and Chetniks had their headquarters in Ravna Gora.

The Territory of the Military Commander in Serbia was the area of the Kingdom of Yugoslavia that was placed under a military government of occupation by the Wehrmacht following the invasion, occupation and dismantling of Yugoslavia in April 1941. The territory included only most of modern central Serbia, with the addition of the northern part of Kosovo, and the Banat. This territory was the only area of partitioned Yugoslavia in which the German occupants established a military government. This was due to the key rail and the Danube transport routes that passed through it, and its valuable resources, particularly non-ferrous metals. On 22 April 1941, the territory was placed under the supreme authority of the German military commander in Serbia, with the day-to-day administration of the territory under the control of the chief of the military administration staff. The lines of command and control in the occupied territory were never unified, and were made more complex by the appointment of direct representatives of senior Nazi figures such as Reichsführer-SS Heinrich Himmler, Reichsmarschall Hermann Göring, and Reichsminister Joachim von Ribbentrop. The Germans used Bulgarian troops to assist in the occupation, but they were at all times under German control. Sources variously describe the territory as a puppet state, a protectorate, a "special administrative province", or describe it as having a puppet government. The military commander in Serbia had very limited German garrison troops and police detachments to maintain order, but could request assistance from a corps of three divisions of poorly-equipped occupation troops.