Vermilion is a town in central Alberta, Canada that is surrounded by the County of Vermilion River. It is at the intersection of Highway 16 and Highway 41, approximately 60 kilometres (37 mi) west of Lloydminster and 192 kilometres (119 mi) east of Edmonton.

Alberta Provincial Highway No. 16, commonly referred to as Highway 16, is a major east–west highway in central Alberta, Canada, connecting Jasper to Lloydminster via Edmonton. It forms a portion of the Yellowhead Highway, a major interprovincial route of the Trans-Canada Highway system that stretches from Masset, British Columbia, to Portage la Prairie, Manitoba, near Winnipeg. Highway 16 spans approximately 634 km (394 mi) from Alberta's border with British Columbia in the west to its border with Saskatchewan in the east. As of 2010, all but less than 96 km (60 mi) of the route was divided, with a minimum of two lanes in each direction. It is designated a core route in Canada's National Highway System.