William Allen, also known as Guilielmus Alanus or Gulielmus Alanus, was an English Cardinal of the Roman Catholic Church. He was an ordained priest, but was never a bishop. His main role was setting up colleges to train English missionary priests with the mission of returning secretly to England to keep Roman Catholicism alive there. Allen assisted in the planning of the Spanish Armada's attempted invasion of England in 1588. It failed badly, but if it had succeeded he would probably have been made Archbishop of Canterbury and Lord Chancellor. The Douai-Rheims Bible, a complete translation into English from Latin, was printed under Allen's orders. His activities were part of the Counter Reformation, but they led to an intense response in England and in Ireland. He advised and recommended Pope Pius V to pronounce Elizabeth I deposed. After the Pope declared her excommunicated and deposed, Elizabeth intensified the persecution of her Roman Catholic religious opponents.

The Douay–Rheims Bible, also known as the Douay–Rheims Version, Rheims–Douai Bible or Douai Bible, and abbreviated as D–R, DRB, and DRV, is a translation of the Bible from the Latin Vulgate into English made by members of the English College, Douai, in the service of the Catholic Church. The New Testament portion was published in Reims, France, in 1582, in one volume with extensive commentary and notes. The Old Testament portion was published in two volumes twenty-seven years later in 1609 and 1610 by the University of Douai. The first volume, covering Genesis to Job, was published in 1609; the second, covering the Book of Psalms to 2 Maccabees plus the three apocryphal books of the Vulgate appendix following the Old Testament, was published in 1610. Marginal notes took up the bulk of the volumes and offered insights on issues of translation, and on the Hebrew and Greek source texts of the Vulgate.