(+)-camphene synthase

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(+)-camphene synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(+)-camphene synthase (EC is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, (+)-camphene-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

geranyl diphosphate (+)-camphene + diphosphate

Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-alpha-pinene.


  1. ^ Gambliel, H.; Croteau, R. (1984). "Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration". J. Biol. Chem. 259 (2): 740–748. PMID 6693393. 
  2. ^ Croteau, R.; Satterwhite, D.M.; Cane, D.E.; Chang, C.C. (1988). "Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (−)-linalyl pyrophosphate to (+)- and (−)-pinene and (+)- and (−)-camphene". J. Biol. Chem. 263 (21): 10063–10071. PMID 3392006. 
  3. ^ Wagschal, K.C.; Pyun, H.J.; Coates, R.M.; Croteau, R. (1994). "Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis)". Arch. Biochem. Biophys. 308: 477–487. doi:10.1006/abbi.1994.1068. PMID 8109978. 
  4. ^ Pyun, H.J.; Wagschal, K.C.; Jung, D.I.; Coates, R.M.; Croteau, R. (1994). "Stereochemistry of the proton elimination in the formation of (+)- and (−)-α-pinene by monoterpene cyclases from sage (Salvia officinalis)". Arch. Biochem. Biophys. 308: 488–496. doi:10.1006/abbi.1994.1069. PMID 8109979. 

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