(+)-car-3-ene synthase

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(+)-car-3-ene synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(+)-car-3-ene synthase (EC, 3-carene cyclase, 3-carene synthase, 3CAR, (+)-3-carene synthase) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, (+)-car-3-ene-forming).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

geranyl diphosphate (+)-car-3-ene + diphosphate

The enzyme reacts with (3S)-linalyl diphosphate twice as rapidly as geranyl diphosphate.


  1. ^ Savage, T.J.; Croteau, R. (1993). "Biosynthesis of monoterpenes: regio- and stereochemistry of (+)-3-carene biosynthesis". Arch. Biochem. Biophys. 305: 581–587. doi:10.1006/abbi.1993.1464. PMID 8373196. 
  2. ^ Savage, T.J.; Ichii, H.; Hume, S.D.; Little, D.B.; Croteau, R. (1995). "Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents". Arch. Biochem. Biophys. 320: 257–265. doi:10.1016/0003-9861(95)90008-x. PMID 7625832. 
  3. ^ Savage, T.J.; Hatch, M.W.; Croteau, R. (1994). "Monoterpene synthases of Pinus contorta and related conifers. A new class of terpenoid cyclase". J. Biol. Chem. 269: 4012–4020. PMID 8307957. 
  4. ^ Faldt, J.; Martin, D.; Miller, B.; Rawat, S.; Bohlmann, J. (2003). "Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase". Plant Mol. Biol. 51: 119–133. doi:10.1023/A:1020714403780. PMID 12602896. 
  5. ^ Hamberger, B.; Hall, D.; Yuen, M.; Oddy, C.; Hamberger, B.; Keeling, C.I.; Ritland, C.; Ritland, K.; Bohlmann, J. (2009). "Targeted isolation, sequence assembly and characterization of two white spruce (Picea glauca) BAC clones for terpenoid synthase and cytochrome P450 genes involved in conifer defence reveal insights into a conifer genome". BMC Plant Biol. 9: #106–106. doi:10.1186/1471-2229-9-106. PMC 2729077Freely accessible. PMID 19656416. 
  6. ^ Hall, D.E.; Robert, J.A.; Keeling, C.I.; Domanski, D.; Quesada, A.L.; Jancsik, S.; Kuzyk, M.A.; Hamberger, B.; Borchers, C.H.; Bohlmann, J. (2011). "An integrated genomic, proteomic and biochemical analysis of (+)-3-carene biosynthesis in Sitka spruce (Picea sitchensis) genotypes that are resistant or susceptible to white pine weevil". Plant J. 65: 936–948. doi:10.1111/j.1365-313x.2010.04478.x. PMID 21323772. 

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