Miltiradiene synthase

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Miltiradiene synthase
Identifiers
EC number 4.2.3.131
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Miltiradiene synthase (EC 4.2.3.131, SmMDS, SmiKSL) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming).[1][2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate miltiradiene + diphosphate

This enzyme is isolated from the plant Selaginella moellendorffii.

References[edit]

  1. ^ Gao, W., Hillwig, M.L., Huang, L., Cui, G., Wang, X., Kong, J., Yang, B. and Peters, R.J. (2009). "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights". Org. Lett. 11: 5170–5173. doi:10.1021/ol902051v. PMC 2776380Freely accessible. PMID 19905026. 
  2. ^ Sugai, Y., Ueno, Y., Hayashi, K., Oogami, S., Toyomasu, T., Matsumoto, S., Natsume, M., Nozaki, H. and Kawaide, H. (2011). "Enzymatic 13C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii". J. Biol. Chem. 286: 42840–42847. doi:10.1074/jbc.m111.302703. PMC 3234827Freely accessible. PMID 22027823. 

External links[edit]