Levopimaradiene synthase

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Levopimaradiene synthase
Identifiers
EC number 4.2.3.32
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Levopimaradiene synthase (EC 4.2.3.32, PtTPS-LAS, LPS, copalyl-diphosphate diphosphate-lyase [abieta-8(14),12-diene-forming]) is an enzyme with systematic name (+)-copalyl-diphosphate diphosphate-lyase (abieta-8(14),12-diene-forming).[1][2] This enzyme catalyses the following chemical reaction

(+)-copalyl diphosphate abieta-8(14),12-diene + diphosphate

In Ginkgo, the enzyme catalyses the initial cyclization step in the biosynthesis of ginkgolides.

References[edit]

  1. ^ Schepmann, H.G.; Pang, J.; Matsuda, S.P. (2001). "Cloning and characterization of Ginkgo biloba levopimaradiene synthase which catalyzes the first committed step in ginkgolide biosynthesis". Arch. Biochem. Biophys. 392 (2): 263–269. doi:10.1006/abbi.2001.2438. PMID 11488601. 
  2. ^ Ro, D.K.; Bohlmann, J. (2006). "Diterpene resin acid biosynthesis in loblolly pine (Pinus taeda): functional characterization of abietadiene/levopimaradiene synthase (PtTPS-LAS) cDNA and subcellular targeting of PtTPS-LAS and abietadienol/abietadienal oxidase (PtAO, CYP720B1)". Phytochemistry. 67: 1572–1578. doi:10.1016/j.phytochem.2006.01.011. PMID 16497345. 

External links[edit]