Epi-isozizaene 5-monooxygenase

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Epi-isozizaene 5-monooxygenase
Identifiers
EC number 1.14.13.106
CAS number 1207718-51-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Epi-isozizaene 5-monooxygenase (EC 1.14.13.106, CYP170A1) is an enzyme with systematic name (+)-epi-isozizaene,NADPH:oxygen oxidoreductase (5-hydroxylating).[1] This enzyme catalyses the following chemical reaction

(+)-epi-isozizaene + 2 NADPH + 2 H+ + 2 O2 albaflavenone + 2 NADP+ + 3 H2O (overall reaction)
(1a) (+)-epi-isozizaene + NADPH + H+ + O2 (5S)-albaflavenol + NADP+ + H2O
(1b) (5S)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O
(2a) (+)-epi-isozizaene + NADPH + H+ + O2 (5R)-albaflavenol + NADP+ + H2O
(2b) (5R)-albaflavenol + NADPH + H+ + O2 albaflavenone + NADP+ + 2 H2O

This cytochrome P450 enzyme is purified from bacterium Streptomyces coelicolor.

References[edit]

  1. ^ Zhao, B.; Lin, X.; Lei, L.; Lamb, D.C.; Kelly, S.L.; Waterman, M.R.; Cane, D.E. (2008). "Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2)". J. Biol. Chem. 283 (13): 8183–8189. doi:10.1074/jbc.M710421200. PMC 2276382Freely accessible. PMID 18234666. 

External links[edit]