Germacrene A hydroxylase

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Germacrene A hydroxylase
Identifiers
EC number 1.14.13.123
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Germacrene A hydroxylase (EC 1.14.13.123) is an enzyme with systematic name (+)-germacrene-A,NADPH:oxygen oxidoreductase (12-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

(+)-germacrene A + NADPH + H+ + O2 germacra-1(10),4,11(13)-trien-12-ol + NADP+ + H2O

Germacrene A hydroxylase is a heme-thiolate protein (P-450).

References[edit]

  1. ^ de Kraker, J.W.; Franssen, M.C.; Dalm, M.C.; de Groot, A.; Bouwmeester, H.J. (2001). "Biosynthesis of germacrene A carboxylic acid in chicory roots. Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis". Plant Physiol. 125: 1930–1940. doi:10.1104/pp.125.4.1930. PMC 88848Freely accessible. PMID 11299372. 
  2. ^ Nguyen, D.T.; Gopfert, J.C.; Ikezawa, N.; Macnevin, G.; Kathiresan, M.; Conrad, J.; Spring, O.; Ro, D.K. (2010). "Biochemical conservation and evolution of germacrene A oxidase in asteraceae". J. Biol. Chem. 285: 16588–16598. doi:10.1074/jbc.M110.111757. PMC 2878029Freely accessible. PMID 20351109. 

External links[edit]