(+)-Menthofuran synthase

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(+)-Menthofuran synthase
Identifiers
EC number 1.14.13.104
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

(+)-Menthofuran synthase (EC 1.14.13.104, menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

(+)-pulegone + NADPH + H+ + O2 (+)-menthofuran + NADP+ + H2O

Menthofuran synthase is a heme-thiolate protein (P-450).

References[edit]

  1. ^ Bertea, C.M.; Schalk, M.; Karp, F.; Maffei, M.; Croteau, R. (2001). "Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene". Arch. Biochem. Biophys. 390 (2): 279–286. doi:10.1006/abbi.2001.2378. PMID 11396930. 
  2. ^ Mahmoud, S.S.; Croteau, R.B. (2003). "Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase". Proc. Natl. Acad. Sci. USA. 100 (24): 14481–14486. doi:10.1073/pnas.2436325100. PMC 283617Freely accessible. PMID 14623962. 

External links[edit]