Bay K8644

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Bay K8644[1]
Skeletal formula of bay K8644
Space-filling model of the bay K8644 molecule
IUPAC name
Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
3D model (JSmol)
ECHA InfoCard 100.163.930
Molar mass 356.30 g·mol−1
Solubility in other solvents DMSO: 184 mg/mL; methanol and ethanol: 63 mg/mL
R-phrases (outdated) R36/38
S-phrases (outdated) S26 S36
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Bay K8644 is a chemical compound that functions as a calcium channel agonist. Bay K8644 is used primarily as a biochemical research tool for this effect.[2] It is a structural analog of nifedipine with positive inotropic activity, and as an aromatic it is highly lipid soluble.

Mechanism of Action[edit]

Bay K8644 targets Voltage-sensitive dihydropyridine (DHP) Calcium Channels (L-Type). It is the first positive inotropic agent shown to act specifically and directly on calcium channels.[3]


  1. ^ (±)-Bay K8644[permanent dead link] at Sigma-Aldrich
  2. ^ Bay K8644 at PubChem
  3. ^ Thomas, G; Chung, M; Cohen, CJ (January 1985). "A dihydropyridine (Bay k 8644) that enhances calcium currents in guinea pig and calf myocardial cells. A new type of positive inotropic agent". Circ Res. 56: 87–96. doi:10.1161/01.res.56.1.87. PMID 2578336.