RTI-32

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RTI-32
RTI-32 structure.png
Identifiers
CAS Number
PubChem CID
ChemSpider
ChEMBL
Chemical and physical data
Formula C17H23NO2
Molar mass 273.370 g/mol
3D model (JSmol)
  (verify)

(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-4229-32, tolpane) is a phenyltropane-based cocaine analogue that has similar properties in vitro to related drugs such as RTI-31.[1][2]

Comparison of Data
Compound DAT DA NET NA SERT 5HT ED50
Troparil 23 49.8 550 37.2 178 173 0.34
RTI-32 1.7 7.02 36 8.42 23 19.4 0.31
RTI-31 1.1 3.68 22 5.86 4.0 5.0 0.13
3'4'-xylyl 0.43 unknown 44 unknown 2.42 unknown

See also[edit]

References[edit]

  1. ^ Remy, Philippe; Doder, Miroslava; Lees, Andrew; Turjanski, Nora; Brooks, David (1 June 2005). "Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system". Brain. 128 (6): 1314–1322. doi:10.1093/brain/awh445. PMID 15716302. 
  2. ^ Xu, Lifen; Izenwasser, Sari; Katz, Jonathan L.; Kopajtic, Theresa; Klein-Stevens, Cheryl; Zhu, Naiju; Lomenzo, Stacey A.; Winfield, Leyte; Trudell, Mark L. (1 March 2002). "Synthesis and Biological Evaluation of 2-Substituted 3β-Tolyltropane Derivatives at Dopamine, Serotonin, and Norepinephrine Transporters". Journal of Medicinal Chemistry. 45 (6): 1203–1210. doi:10.1021/jm010453u. PMID 11881989.