Premnaspirodiene oxygenase

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Premnaspirodiene oxygenase
Identifiers
EC number 1.14.13.121
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Premnaspirodiene oxygenase (EC 1.14.13.121, HPO, Hyoscymus muticus premnaspirodiene oxygenase) is an enzyme with systematic name (-)-vetispiradiene,NADPH:oxygen 2alpha-oxidoreductase.[1] This enzyme catalyses the following chemical reaction

(-)-vetispiradiene + 2 NADPH + 2 H+ + 2 O2 solavetivone + 2 NADP+ + 3 H2O (overall reaction)
(1a) (-)-vetispiradiene + NADPH + H+ + O2 solavetivol + NADP+ + H2O
(1b) solavetivol + NADPH + H+ + O2 solavetivone + NADP+ + 2 H2O

Premnaspirodiene oxygenase heme-thiolate protein (P-450).

References[edit]

  1. ^ Takahashi, S.; Yeo, Y.S.; Zhao, Y.; O'Maille, P.E.; Greenhagen, B.T.; Noel, J.P.; Coates, R.M.; Chappell, J. (2007). "Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates". J. Biol. Chem. 282 (43): 31744–31754. doi:10.1074/jbc.M703378200. PMC 2695360Freely accessible. PMID 17715131. 

External links[edit]