Indole-3-glycerol-phosphate lyase

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Indole-3-glycerol-phosphate lyase
Identifiers
EC number 4.1.2.8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, an indole-3-glycerol-phosphate lyase (EC 4.1.2.8) is an enzyme that catalyzes the chemical reaction

(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate indole + D-glyceraldehyde 3-phosphate

Hence, this enzyme has one substrate, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and two products, indole and D-glyceraldehyde 3-phosphate.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds, the systematic name of this enzyme class is (1S,2R)-1-C-(indol-3-yl)glycerol-3-phosphate D-glyceraldehyde-3-phosphate-lyase (indole-forming). Other names in common use include tryptophan synthase alpha, TSA, indoleglycerolphosphate aldolase, indole glycerol phosphate hydrolase, indole synthase, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase, indole-3-glycerol phosphate lyase, IGL, BX1, (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate, and D-glyceraldehyde-3-phosphate-lyase. This enzyme participates in benzoxazinone biosynthesis.

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