Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)

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Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific)
Identifiers
EC number 2.5.1.87
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Ditrans,polycis-polyprenyl diphosphate synthase ((2E,6E)-farnesyl diphosphate specific) (EC 2.5.1.87, RER2, Rer2p, Rer2p Z-prenyltransferase, Srt1p, Srt2p Z-prenyltransferase, ACPT, dehydrodolichyl diphosphate synthase 1) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate cistransferase (adding 10--55 isopentenyl units).[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + n isopentenyl diphosphate n diphosphate + ditrans,polycis-polyprenyl diphosphate (n 10--55)

The enzyme is involved in biosynthesis of dolichol (a long-chain polyprenol) with a saturated alpha-isoprene unit.

References[edit]

  1. ^ Sato, M.; Fujisaki, S.; Sato, K.; Nishimura, Y.; Nakano, A. (2001). "Yeast Saccharomyces cerevisiae has two cis-prenyltransferases with different properties and localizations. Implication for their distinct physiological roles in dolichol synthesis". Genes Cells. 6 (6): 495–506. doi:10.1046/j.1365-2443.2001.00438.x. PMID 11442630. 
  2. ^ Poznanski, J.; Szkopinska, A. (2007). "Precise bacterial polyprenol length control fails in Saccharomyces cerevisiae". Biopolymers. 86 (2): 155–164. doi:10.1002/bip.20715. PMID 17345630. 
  3. ^ Sato, M.; Sato, K.; Nishikawa, S.; Hirata, A.; Kato, J.; Nakano, A. (1999). "The yeast RER2 gene, identified by endoplasmic reticulum protein localization mutations, encodes cis-prenyltransferase, a key enzyme in dolichol synthesis". Mol. Cell. Biol. 19 (1): 471–483. doi:10.1128/mcb.19.1.471. PMC 83905Freely accessible. PMID 9858571. 
  4. ^ Oh, S.K.; Han, K.H.; Ryu, S.B.; Kang, H. (2000). "Molecular cloning, expression, and functional analysis of a cis-prenyltransferase from Arabidopsis thaliana. Implications in rubber biosynthesis". J. Biol. Chem. 275 (24): 18482–18488. doi:10.1074/jbc.M002000200. PMID 10764783. 
  5. ^ Cunillera, N.; Arro, M.; Fores, O.; Manzano, D.; Ferrer, A. (2000). "Characterization of dehydrodolichyl diphosphate synthase of Arabidopsis thaliana, a key enzyme in dolichol biosynthesis". FEBS Lett. 477 (3): 170–174. doi:10.1016/S0014-5793(00)01798-1. PMID 10908715. 

External links[edit]