All-trans-octaprenyl-diphosphate synthase

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All-trans-octaprenyl-diphosphate synthase
PDB 1v4e EBI.jpg
Identifiers
EC number 2.5.1.90
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

All-trans-octaprenyl-diphosphate synthase (EC 2.5.1.90, octaprenyl-diphosphate synthase, octaprenyl pyrophosphate synthetase, polyprenylpyrophosphate synthetase, terpenoidallyltransferase, terpenyl pyrophosphate synthetase, trans-heptaprenyltranstransferase, trans-prenyltransferase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 5 isopentenyl units).[1][2] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + 5 isopentenyl diphosphate 5 diphosphate + all-trans-octaprenyl diphosphate

This enzyme catalyses the condensation reactions resulting in the formation of all-trans-octaprenyl diphosphate.

References[edit]

  1. ^ Fujisaki, S.; Nishino, T.; Katsuki, H. (1986). "Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis". J. Biochem. 99 (5): 1327–1337. PMID 3519603. 
  2. ^ Asai, K.; Fujisaki, S.; Nishimura, Y.; Nishino, T.; Okada, K.; Nakagawa, T.; Kawamukai, M.; Matsuda, H. (1994). "The identification of Escherichia coli ispB (cel) gene encoding the octaprenyl diphosphate synthase". Biochem. Biophys. Res. Commun. 202 (1): 340–345. doi:10.1006/bbrc.1994.1933. PMID 8037730. 

External links[edit]