Patchoulol synthase

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Patchoulol synthase
Identifiers
EC number 4.2.3.70
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Patchoulol synthase (EC 4.2.3.70) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (patchoulol-forming).[1][2][3] This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate + H2O patchoulol + diphosphate

References[edit]

  1. ^ Croteau, R.; Munck, S.L.; Akoh, C.C.; Fisk, H.J.; Satterwhite, D.M. (1987). "Biosynthesis of the sesquiterpene patchoulol from farnesyl pyrophosphate in leaf extracts of Pogostemon cablin (patchouli): mechanistic considerations". Arch. Biochem. Biophys. 256: 56–68. doi:10.1016/0003-9861(87)90425-5. PMID 3038029. 
  2. ^ Munck, S.L.; Croteau, R. (1990). "Purification and characterization of the sesquiterpene cyclase patchoulol synthase from Pogostemon cablin". Arch. Biochem. Biophys. 282: 58–64. doi:10.1016/0003-9861(90)90086-e. PMID 2171435. 
  3. ^ Faraldos, J.A.; Wu, S.; Chappell, J.; Coates, R.M. (2010). "Doubly deuterium-labeled patchouli alcohol from cyclization of singly labeled [2-2H1]farnesyl diphosphate catalyzed by recombinant patchoulol synthase". J. Am. Chem. Soc. 132: 2998–3008. doi:10.1021/ja909251r. PMID 20148554. 

External links[edit]