Phosphosulfolactate synthase

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phosphosulfolactate synthase
Identifiers
EC number 4.4.1.19
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a phosphosulfolactate synthase (EC 4.4.1.19) is an enzyme that catalyzes the chemical reaction

(2R)-2-O-phospho-3-sulfolactate phosphoenolpyruvate + hydrogen sulfite

Hence, this enzyme has one substrate, (2R)-2-O-phospho-3-sulfolactate, and two products, phosphoenolpyruvate and hydrogen sulfite.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases, the systematic name of this enzyme class is (2R)-2-O-phospho-3-sulfolactate hydrogen-sulfite-lyase (phosphoenolpyruvate-forming). Other names in common use include (2R)-phospho-3-sulfolactate synthase, and (2R)-O-phospho-3-sulfolactate sulfo-lyase.

Structural studies[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1U83.

References[edit]

  • Graham DE, Xu H, White RH (2002). "Identification of coenzyme M biosynthetic phosphosulfolactate synthase: a new family of sulfonate-biosynthesizing enzymes". J. Biol. Chem. 277 (16): 13421–9. doi:10.1074/jbc.M201011200. PMID 11830598.