2-Amino-4-deoxychorismate dehydrogenase

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2-amino-4-deoxychorismate dehydrogenase
Identifiers
EC number 1.3.99.24
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.99.24, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

(2S)-2-amino-4-deoxychorismate + FMN 3-(1-carboxyvinyloxy)anthranilate + FMNH2

This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].

References[edit]

  1. ^ Van Lanen, S.G.; Lin, S.; Shen, B. (2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proc. Natl. Acad. Sci. USA. 105: 494–499. doi:10.1073/pnas.0708750105. PMC 2206564Freely accessible. PMID 18182490. 
  2. ^ Yu, L.; Mah, S.; Otani, T.; Dedon, P. (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117: 8877–8878. doi:10.1021/ja00139a032. 

External links[edit]