Crotonyl-CoA carboxylase/reductase

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Crotonyl-CoA carboxylase/reductase
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Crotonyl-CoA carboxylase/reductase tetramer, Streptomyces sp. NRRL 2288
Identifiers
EC number 1.3.1.85
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Crotonyl-CoA carboxylase/reductase (EC 1.3.1.85, CCR, crotonyl-CoA reductase (carboxylating)) is an enzyme with systematic name (2S)-ethylmalonyl-CoA:NADP+ oxidoreductase (decarboxylating).[1][2] This enzyme catalyses the following chemical reaction

(2S)-ethylmalonyl-CoA + NADP+ (E)-but-2-enoyl-CoA + CO2 + NADPH + H+

The reaction is catalysed in the reverse direction.

References[edit]

  1. ^ Erb, T.J.; Berg, I.A.; Brecht, V.; Muller, M.; Fuchs, G.; Alber, B.E. (2007). "Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway". Proc. Natl. Acad. Sci. USA. 104: 10631–10636. doi:10.1073/pnas.0702791104. PMC 1965564Freely accessible. PMID 17548827. 
  2. ^ Erb, T.J.; Brecht, V.; Fuchs, G.; Muller, M.; Alber, B.E. (2009). "Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase". Proc. Natl. Acad. Sci. USA. 106: 8871–8876. doi:10.1073/pnas.0903939106. PMC 2689996Freely accessible. PMID 19458256. 

External links[edit]