Trans,polycis-decaprenyl diphosphate synthase

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Trans,polycis-decaprenyl diphosphate synthase
Identifiers
EC number 2.5.1.86
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Trans,polycis-decaprenyl diphosphate synthase (EC 2.5.1.86, Rv2361c, (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E)-decaprenyl diphosphate synthase) is an enzyme with systematic name (2Z,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesylcistransferase (adding 7 isopentenyl units) .[1][2][3] This enzyme catalyses the following chemical reaction

(2Z,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate 7 diphosphate + trans,octacis-decaprenyl diphosphate

The enzyme is involved in the biosynthesis of decaprenyl phosphate.

References[edit]

  1. ^ Kaur, D.; Brennan, P.J.; Crick, D.C. (2004). "Decaprenyl diphosphate synthesis in Mycobacterium tuberculosis". J. Bacteriol. 186 (22): 7564–7570. doi:10.1128/JB.186.22.7564-7570.2004. PMC 524883Freely accessible. PMID 15516568. 
  2. ^ Wang, W.; Dong, C.; McNeil, M.; Kaur, D.; Mahapatra, S.; Crick, D.C.; Naismith, J.H. (2008). "The structural basis of chain length control in Rv1086". J. Mol. Biol. 381 (1): 129–140. doi:10.1016/j.jmb.2008.05.060. PMC 2527485Freely accessible. PMID 18597781. 
  3. ^ Crick, D.C.; Schulbach, M.C.; Zink, E.E.; Macchia, M.; Barontini, S.; Besra, G.S.; Brennan, P.J. (2000). "Polyprenyl phosphate biosynthesis in Mycobacterium tuberculosis and Mycobacterium smegmatis". J. Bacteriol. 182 (20): 5771–5778. doi:10.1128/JB.182.20.5771-5778.2000. PMC 94699Freely accessible. PMID 11004176. 

External links[edit]