Z-farnesyl diphosphate synthase

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Z-farnesyl diphosphate synthase
Identifiers
EC number 2.5.1.68
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a Z-farnesyl diphosphate synthase (EC 2.5.1.68) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + isopentenyl diphosphate diphosphate + (2Z,6E)-farnesyl diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and isopentenyl diphosphate, whereas its two products are diphosphate and (2Z,6E)-farnesyl diphosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups, the systematic name of this enzyme class is geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase. This enzyme is also called (Z)-farnesyl diphosphate synthase.

References[edit]

  • F, Bertini S, Brennan PJ, Crick DC (2001). "Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis". J. Biol. Chem. 276 (15): 11624–30. doi:10.1074/jbc.M007168200. PMID 11152452.