3-hydroxybutyryl-CoA dehydratase

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3-hydroxybutyryl-CoA dehydratase
Identifiers
EC number 4.2.1.55
CAS number 37290-82-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO

In enzymology, a 3-hydroxybutyryl-CoA dehydratase (EC 4.2.1.55) is an enzyme that catalyzes the chemical reaction

(3R)-3-hydroxybutanoyl-CoA crotonoyl-CoA + H2O

Hence, this enzyme has one substrate, (3R)-3-hydroxybutanoyl-CoA, and two products, crotonoyl-CoA and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming). Other names in common use include D-3-hydroxybutyryl coenzyme A dehydratase, D-3-hydroxybutyryl-CoA dehydratase, enoyl coenzyme A hydrase (D), and (3R)-3-hydroxybutanoyl-CoA hydro-lyase. This enzyme participates in butanoate metabolism.

References[edit]

  • Moskowitz GJ, Merrick JM (1969). "Metabolism of poly-beta-hydroxybutyrate. II. Enzymatic synthesis of D-(−)-beta hydroxybutyryl coenzyme A by an enoyl hydrase from Rhodospirillum rubrum". Biochemistry. 8 (7): 2748–55. doi:10.1021/bi00835a009. PMID 5808333.